. 2014 May 15;592(Pt 10):2119–2135. doi: 10.1113/jphysiol.2013.268805

Table 5.

Dopamine signalling-related NAc mRNA expression differences between HVR and LVR lines

	HVR_run	LVR_run	HVR_run/		HVR_non-run	LVR_non-run	HVR_non-run/
mRNA	RPKM avg	RPKM avg	LVR_run	P	RPKM avg	RPKM avg	LVR_non-run	P
Adcy5	26.21^{↑ vs. HVRnr}	21.21	1.24	0.08	20.30	21.80	−1.08	0.36
Adcy6	4.07	4.68	−1.15	0.02	4.58	4.84	−1.06	0.55
Arpp19	107.05^{↑ vs. HVRnr}	82.12	1.30	0.03	76.93	82.71^{↓ vs. CTL}	−1.08	0.54
Cav2	7.02^{↓ vs. HVRnr}	8.51	−1.22	0.06	8.53	7.87	1.08	0.28
Caly	142.02	142.84	−1.01	0.90	138.85^{↓ vs. CTL}	135.83^{↓ vs. CTL}	1.02	0.71
Cdnf	0.36	0.38	−1.08	0.83	0.23	0.35	−1.56	0.22
Drd1	81.54^{↑ vs. HVRnr}	65.53	1.24	0.06	58.32	60.44^{↓ vs. CTL}	−1.03	0.77
Drd2	59.03^{↑ vs. HVRnr}	50.26	1.17	0.15	45.29^{↓ vs. CTL}	47.72	−1.06	0.53
Drd3	0.54	0.64	−1.20	0.34	0.71	0.54	1.30	0.32
Drd4	ND	ND	ND	ND	ND	ND	ND	ND
Drd5	1.22^{↑ vs. HVRnr}	1.07	1.13	0.41	0.92	0.99	−1.09	0.56
Dtnbp1	11.64	11.66	−1.01	0.97	11.65	11.46	1.01	0.62
Flna	1.59^{↓ vs. HVRnr}	1.98	−1.25	0.07	2.80	2.10	1.32	0.15
Gna11	15.95^{↑ vs. HVRnr}	15.92	1.00	0.97	12.86	15.37	−1.20	0.02
Gna12	72.63^{↓ vs. HVRnr}	77.26	−1.06	0.16	80.81	83.07	1.03	0.57
Gna15	2.04	2.11	−1.03	0.80	2.05	2.10	−1.02	0.86
Gnal	71.17^{↑ vs. HVRnr}	61.86	1.15	0.07	57.67	59.44	1.03	0.74
Gnaq	33.91	33.15	1.02	0.49	31.73	33.53	1.05	0.24
Gnas	54.31	57.70	−1.06	0.44	55.54^{↓ vs. CTL}	56.46	−1.02	0.71
Gnao1	105.13^{↑ vs. HVRnr}	100.23	1.05	0.30	89.96	102.82	−1.15	0.24
Htt	0.80	0.69^{↓ vs. LVRnr}	1.15	0.06	0.72	0.84	1.16	0.20
Klf16	41.93^{↑ vs. HVRnr}	40.12	1.05	0.45	36.45^{↓ vs. CTL}	38.36^{↓ vs. CTL}	−1.05	0.37
Lrrk2	17.70^{↑ vs. HVRnr}	14.76	1.20	0.09	13.34	14.75	−1.11	0.31
Nsg1	177.37	170.84	1.04	0.31	161.51^{↓ vs. CTL}	161.57^{↓ vs. CTL}	1.00	0.99
Oprd1^*	3.10^{↑ vs. HVRnr}	2.50	1.24	0.02	2.03	2.64	−1.32	0.01
Oprm1	2.05	1.35	1.52	0.01	1.88	1.48	1.27	0.16
Palm	82.97	84.47	−1.02	0.63	88.52	84.94	1.04	0.64
Rgs9	129.27^{↑ vs. HVRnr}	107.27	1.21	0.16	97.37	101.51	1.04	0.69
Slc6a3	0.10^{↓ vs. HVRnr}	0.09	1.10	0.63	0.16	0.10	1.58	0.03
Slc9a3r1	20.79	23.78	−1.15	0.07	21.83	23.35	−1.08	0.49

This gene list was constructed according to the Gene Ontology (GO) dopamine receptor signalling pathway (GO ID: 0007212), adenylate cyclase-activating dopamine receptor pathway (GO ID: 0007191), adenylate cyclase-inhibiting dopamine receptor pathway (GO ID: 0007191), and/or the negative regulation of dopamine receptor signalling pathway (GO ID: 0060160) lists. Abbreviations: HVR_run = HVR 34-day-old 6-day runners, LVR_run = LVR 34-day-old 6-day runners, HVR_non-run= HVR 34-day-old non-runners, LVR_non-run = LVR 34-day-old non-runners, CTL = control Wistar rats; ND = not detected.

Symbols: cited as different between HVR_non-run and LVR_non-run rats in prior publication (Roberts et al. 2013); ↑ vs. CTL = transcript in HVR_non-run or LVR_non-run rats was higher than in CTL rats (P < 0.05); ↓ vs. CTL = transcript in HVR_non-run or LVR_non-run rats was lower than in CTL rats (P < 0.05); ↑ vs. HVR_non-run or LVR_non-run = transcript in HVR_run or LVR_run is greater than HVR_non-run or LVR_non-run rats, respectively (P < 0.05); ↓ vs. HVR_non-run or LVR_non-run = transcript in HVR_run is less than HVR_non-run rats (P < 0.05). These significant differences are in bold type.