Figure 1.
The esx-1 region in M. marinum. The ∼10 Kb genomic region including the Esx-1 secretion system from M. marinum is shown. Genes are named according to Bitter et al.34 Briefly, Esp = Esx secretion-associated proteins; Ecc = Esx conserved components. Subscript “1” indicates the gene is found at the esx-1 locus. Genes include letters based on the order of the genes at the esx-1 locus. Transposon (Tn) insertion strains used in this study are represented with an inverted open triangle. Strains used in this study are in Supplemental Table S1. Deletions are indicated by a dotted line above the genes within the deletion. MMAR_5454 is not conserved in M. tuberculosis. * indicates substrates or components defined in this study.