. Author manuscript; available in PMC: 2015 Dec 20.

Published in final edited form as: Stat Med. 2014 Sep 28;33(29):5097–5110. doi: 10.1002/sim.6310

Table 1.

Operating characteristics of the TACO design under various hypotheses

N	S(%)	n₁	n₂	Null Hypothesis: θ = 0.35				Alternative Hypothesis 1: θ = 0.20
N	S(%)	n₁	n₂	β₃	% Early Stop	Type I error	E(SS)	β₃	% Early Stop	Power	E(SS)
200	25%	50	150	1.26	0.77	0.02	97	3.38	0.06	0.93	191
	50%	100	100	0.90	0.80	0.03	120	2.26	0.01	0.98	199
	75%	150	50	0.76	0.84	0.02	158	1.82	0.001	0.92	200

300	25%	75	225	1.02	0.83	0.02	114	2.54	0.02	0.97	295
	50%	150	150	0.76	0.81	0.03	179	1.82	0.002	0.99	300
	75%	225	75	0.66	0.77	0.04	242	1.78	0.001	0.98	300

400	25%	100	300	0.90	0.80	0.02	159	2.26	0.004	0.99	399
	50%	200	200	0.70	0.79	0.03	243	1.82	0	1	400
	75%	300	100	0.62	0.81	0.04	319	1.70	0	1	400