Table 2.

Operating characteristics of the TACO design under various hypotheses

N	S(%)	n1	n2	Alternative Hypothesis 2: θ = 0.25				Alternative Hypothesis 3: θ = 0.30
				β3	% Early Stop	Power	E(SS)	β3	% Early Stop	Power	E(SS)
200	25%	50	150	1.84	0.24	0.68	164	1.78	0.45	0.40	133
	50%	100	100	0.94	0.08	0.85	192	1.38	0.34	0.43	166
	75%	150	50	0.40	0.06	0.67	197	1.18	0.37	0.25	182
300	25%	75	225	1.20	0.16	0.81	265	1.52	0.42	0.45	205
	50%	150	150	0.40	0.05	0.90	293	1.18	0.40	0.39	241
	75%	225	75	0.24	0.02	0.81	299	1.14	0.23	0.41	283
400	25%	100	300	0.94	0.10	0.89	371	1.38	0.37	0.52	289
	50%	200	200	0.40	0.02	0.96	397	1.18	0.22	0.59	357
	75%	300	100	1.24*	0.01	0.92	399	1.10	0.16	0.51	384

Note: The unusual β₃ value (*) may be due to the relatively small number of simulation runs (1,000 simulations).