Table II.
Odds ratios and 95% confidence intervals of BPH for 17 candidate single nucleotide polymorphisms in the CLUE II cohort of Washington County, Maryland
| Genotype | Cases, N | Controls, N | OR (95% CI)* |
|---|---|---|---|
| IL10 | |||
| −592C>A (rs1800872) | |||
| C/C | 306 | 298 | 1.00 (Reference) |
| A/C | 194 | 209 | 0.90 (0.70-1.16) |
| A/A | 23 | 25 | 0.89 (0.50-1.61) |
| Ptrend † | 0.43 | ||
| A-carrier | 217 | 234 | 0.90 (0.71-1.15) |
| −1082A>G (rs1800896) | |||
| A/A | 147 | 138 | 1.00 (Reference) |
| A/G | 285 | 303 | 0.88 (0.66-1.17) |
| G/G | 116 | 110 | 0.99 (0.69-1.40) |
| Ptrend † | 0.88 | ||
| G-carrier | 401 | 413 | 0.91 (0.69-1.19) |
| CRP | |||
| 1082C>T (rs1205) | |||
| C/C | 250 | 273 | 1.00 (Reference) |
| C/T | 237 | 225 | 1.15 (0.89-1.47) |
| T/T | 58 | 47 | 1.34 (0.88-2.05) |
| Ptrend † | 0.11 | ||
| T-carrier | 295 | 272 | 1.18 (0.93-1.50) |
| 1059G>C (rs1800947) | |||
| G/G | 500 | 495 | 1.00 (Reference) |
| C/G | 52 | 50 | 1.03 (0.68-1.54) |
| C/C | 0 | 1 | Not estimated |
| Ptrend † | 0.96 | ||
| C-carrier | 52 | 51 | 1.01 (0.67-1.51) |
| TLR4 | |||
| 11381G>C (rs11536889) | |||
| G/G | 396 | 399 | 1.00 (Reference) |
| C/G | 134 | 128 | 1.05 (0.79-1.39) |
| C/C | 15 | 18 | 0.84 (0.41-1.69) |
| Ptrend † | 0.99 | ||
| C-carrier | 149 | 146 | 1.02 (0.78-1.34) |
| 896A>G [Asp299Gly] (rs4986790) | |||
| A/A | 489 | 491 | 1.00 (Reference) |
| A/G | 62 | 58 | 1.07 (0.73-1.56) |
| G/G | 2 | 3 | 0.67 (0.11-4.02) |
| Ptrend † | 0.86 | ||
| G-carrier | 64 | 61 | 1.05 (0.72-1.52) |
| IL6 | |||
| −174G>C (rs1800795) | |||
| G/G | 177 | 177 | 1.00 (Reference) |
| C/G | 254 | 269 | 0.94 (0.72-1.23) |
| C/C | 99 | 86 | 1.15 (0.80-1.64) |
| Ptrend † | 0.58 | ||
| C-carrier | 353 | 355 | 1.00 (0.77-1.28) |
| −572G>C (rs1800796) | |||
| G/G | 482 | 478 | 1.00 (Reference) |
| C/G | 43 | 57 | 0.74 (0.49-1.13) |
| C/C | 2 | 2 | 1.00 (0.13-7.07) |
| Ptrend † | 0.21 | ||
| C-carrier | 45 | 59 | 0.75 (0.50-1.13) |
| −597G>A (rs1800797) | |||
| G/G | 182 | 189 | 1.00 (Reference) |
| A/G | 261 | 266 | 1.02 (0.78-1.32) |
| A/A | 98 | 80 | 1.27 (0.88-1.82) |
| Ptrend † | 0.25 | ||
| A-carrier | 359 | 346 | 1.08 (0.83-1.38) |
| IL1B | |||
| −31C>T (rs1143627) | |||
| T/T | 233 | 236 | 1.00 (Reference) |
| C/T | 232 | 241 | 0.97 (0.75-1.25) |
| C/C | 72 | 68 | 1.07 (0.73-1.56) |
| Ptrend † | 0.83 | ||
| C-carrier | 304 | 309 | 1.00 (0.78-1.26) |
| IL8 | |||
| −251A>T (rs4073) | |||
| T/T | 151 | 145 | 1.00 (Reference) |
| A/T | 254 | 284 | 0.85 (0.65-1.14) |
| A/A | 132 | 109 | 1.16 (0.82-1.63) |
| Ptrend † | 0.46 | ||
| A-carrier | 386 | 493 | 0.94 (0.72-1.23) |
| TNF | |||
| −308G>A (rs1800629) | |||
| G/G | 361 | 377 | 1.00 (Reference) |
| A/G | 158 | 150 | 1.10 (0.84-1.43) |
| A/A | 17 | 16 | 1.11 (0.55-2.22) |
| Ptrend † | 0.48 | ||
| A-carrier | 175 | 166 | 1.10 (0.85-1.42) |
| RNASEL | |||
| −1385G>A [Arg462Gln] (rs486907) | |||
| G/G | 213 | 224 | 1.00 (Reference) |
| A/G | 244 | 242 | 1.06 (0.81-1.37) |
| A/A | 74 | 69 | 1.12 (0.77-1.64) |
| Ptrend † | 0.51 | ||
| A-carrier | 318 | 311 | 1.08 (0.84-1.37) |
| PPARG | |||
| −49C>G [Pro12Ala] (rs1801282) | |||
| C/C | 427 | 408 | 1.00 (Reference) |
| C/G | 103 | 125 | 0.78 (0.58-1.05) |
| G/G | 7 | 10 | 0.66 (0.25-1.77) |
| Ptrend † | 0.08 | ||
| G-carrier | 110 | 135 | 0.77 (0.58-1.03) |
| TCF7L2 | |||
| 47833T>C (rs7903146) | |||
| C/C | 250 | 261 | 1.00 (Reference) |
| C/T | 222 | 224 | 1.03 (0.80-1.33) |
| T/T | 52 | 38 | 1.42 (0.90-2.24) |
| Ptrend * | 0.22 | ||
| T-carrier | 274 | 262 | 1.09 (0.85-1.39) |
| ADIPOQ | |||
| 276C>A (rs1501299) | |||
| C/C | 271 | 281 | 1.00 (Reference) |
| A/C | 209 | 213 | 1.01 (0.79-1.31) |
| A/A | 59 | 48 | 1.27 (0.84-1.93) |
| Ptrend * | 0.36 | ||
| A-carrier | 268 | 261 | 1.06 (0.83-1.35) |
| LEP | |||
| −19G>A (rs2167270) | |||
| G/G | 211 | 201 | 1.00 (Reference) |
| A/G | 248 | 272 | 0.86 (0.67-1.12) |
| A/A | 74 | 66 | 1.06 (0.72-1.56) |
| Ptrend * | 0.87 | ||
| A-carrier | 322 | 338 | 0.90 (0.70-1.16) |
*
From a logistic regression model adjusting for age. Cases and controls frequency-matched on age.
†
From a logistic regression model with number of variant alleles entered as an ordinal variable.