Table IV Odds ratios and 95% confidence intervals of BPH for IL10, CRP, and TLR4 haplotypes in the CLUE II cohort of Washington County, Maryland

Haplotype¶	Haplotype frequency		OR (95% CI)**
	Cases	Controls
IL10†	N=465	N=472
A-C-A-C-C-C-A	0.327	0.321	1.00 (Reference)
T-C-A-C-C-T-G	0.221	0.211	1.04 (0.80-1.34)
T-C-A-C-C-T-A	0.166	0.145	1.13 (0.86-1.50)
A-C-A-T-C-C-A	0.125	0.119	1.03 (0.75-1.40)
A-C-C-T-C-C-A	0.051	0.066	0.73 (0.48-1.11)
P global ††			0.20
CRP*	N=487	N=494
T-T-T-A	0.342	0.309	1.00 (Reference)
T-A-T-A	0.313	0.315	0.89 (0.71-1.12)
C-T-C-A	0.271	0.296	0.83 (0.66-1.04)
T-T-T-C	0.067	0.070	0.85 (0.59-1.23)
P global ††			0.57
TLR4‡	N=351	N=358
A-T-A-G-G-G-T-C	0.657	0.658	1.00 (Reference)
G-C-G-A-T-C-C-A	0.130	0.140	0.91 (0.66-1.25)
G-C-G-A-T-G-T-C	0.107	0.110	0.97 (0.69-1.37)
G-T-G-G-T-G-T-C	0.061	0.060	1.02 (0.65-1.60)
P global ††			0.76

^†TagSNPs: rs1800890, rs1800894, rs3021094, rs1554286, rs3024509, rs3024496, and rs3024498

^*TagSNPs: rs2794521, rs1417938, rs2808630, and rs3093077

^‡TagSNPs: rs2737190, rs10116253, rs1927914, rs1927911, rs2149356, rs7873784, rs11536891, and rs11536898

^¶Haplotypes shown if present in ≥5% of men; haplotypes were missing due to missing genotype for one or more SNPs for IL10 – cases 18.1%, controls 16.9%; CRP – cases 14.3%, controls 13.0%; and TLR4 – cases 18.1%, controls 16.9%.

^**From a generalized linear model using regression substitution adjusted for age.

^††From a global score test of differences in distribution of haplotype frequencies between cases and controls adjusting for age.