Table 3.
The p-values of GEI tests for the top three (ranks in parentheses) single-nucleotide polymorphisms (SNPs) by using Tukey’s model, the proposed shrinkage estimator, and saturated interaction model within iron gene regions in the NAS data (adjusted α = 5.6 × 10−4).
| Bone Lead | SNP ID | Gene | Tukey LRT | Shrinkage Wald | Saturated LRT |
|---|---|---|---|---|---|
| Tibia | rs1799945 | HFE | 0.003 (1) | 1 × 10−4 (1) | 0.006 (1) |
| rs2285228 | DMT1 | 0.005 (2) | 0.001 (2) | 0.017 (2) | |
| rs3821716 | MFI2 | 0.014 (3) | 0.012 | 0.120 | |
| rs422982 | DMT1 | 0.016 | 0.003 (3) | 0.072 (3) | |
|
| |||||
| Patella | rs7165535 | B2M | 0.001 (1) | 4 × 10−4 (2) | 0.014 (1) |
| rs17484524 | IREB2 | 0.002 (2) | 3 × 10−4 (1) | 0.021 (2) | |
| rs7866419 | ACO1 | 0.009 (3) | 0.005 | 0.054 | |
| rs1358024 | TF | 0.016 | 0.004 (3) | 0.038 | |
| rs2304704 | SLC40A1 | 0.044 | 0.030 | 0.034 (3) | |