Table 1.
Baseline characteristics of the two study groups.
| Variable | IV tPA (n=41) | Sonothrombolysis (n=44) | P value |
|---|---|---|---|
| Sex, male, n (%) | 18 (44) | 30 (68) | 0.024 |
| Age, years (mean±SD) | 73±12 | 70±10 | 0.35 |
| Vascular risk factors, n (%) | |||
| Arterial hypertension | 22 (54) | 28 (64) | 0.35 |
| Nicotine | 7 (17) | 12 (27) | 0.26 |
| Diabetes mellitus | 12 (29) | 9 (20) | 0.35 |
| Atrial fibrillation | 11 (27) | 11 (25) | 0.85 |
| NIHSS, median (IQR) | 18 (14-20) | 17 (14-21) | 0.85 |
| TIBI, median (IQR) | 2 (1-3) | 2 (1-2) | 0.75 |
| M1 MCA occlusion, n (%) | 32 (78) | 35 (80) | 0.87 |
| M2 MCA occlusion, n (%) | 9 (22) | 9 (20) | 0.87 |
| ICA obstruction*, n (%) | 10 (24) | 15 (34) | 0.35 |
| Pretreatment SBP, mmHg (mean±SD) | 156±23 | 160±22 | 0.38 |
| Insonation depth, mm (mean±SD) | 51±8 | 50±7 | 0.45 |
| OTT time, min (mean±SD) | 135±32 | 144±30 | 0.19 |
IV indicates intravenous; tPA, tissue plasminogen activator; SD, standard deviation; IQR, interquartile range; NIHSS, National Institutes of Health Stroke Scale; TIBI, Thrombolysis In Brain Ischemia; MCA, middle cerebral artery; ICA, internal carotid artery; OTT, onset to treatment; SBP, systolic blood pressure
*
concomitant greater or equal than 70% stenosis or complete occlusion of the proximal ICA