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Anti-apoptotic function of gal-7 is not altered by R74S mutation. Effect of wild-type and mutated gal-7 on (A) PARP-1 cleavage and (B) Annexin V positive cells induced upon treatment with 150 μM CoCl2. (C) Western blot analysis of PARP-1 cleavage for increasing doses of etoposide for 24 hrs at 37°C. Controls included stable MCF-7 cells transfected with the empty (srα) expression vector.
