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. 2014 Oct 28;12:89. doi: 10.1186/s12915-014-0089-x

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© Wang et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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5′-Extension of TRM12 mRNA leads to reduced Trm12 protein levels. A) IGV profiles showing apparent approximately 800 base extension of TRM12 mRNA in tfc6 mutant. B) Extended TRM12 5′-UTR levels are relatively low in tfc6 mutants, but much more abundant in tS(AGA)M B-box mutants DDY5162 and DDY5163. Extended RNAs were detected by RT-PCR as in previous figures. C) Western blot of TRM12-9 × -myc strains shows reduced Trm12 protein levels in the B-box mutants. TRM12-9 × -myc tagged strains are: wild type, DDY5170 and DDY5171; tfc6, DDY5172 and DDY5173; and ts(aga)m b-box, DDY5174, DDY5205 and DDY5206. IGV, integrative genomics viewer.