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. 2014 Nov 3;6(10):93. doi: 10.1186/s13073-014-0093-3

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© Hanses et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Endocarditis was more severe in diabetic rats than in nondiabetic rats. (A) Diabetic animals had significantly higher levels of bacteremia on day 2 and day 3 after bacterial challenge. (B) Diabetic animals had larger vegetations, and (C) the vegetations were associated with a significantly higher bacterial burden. (D) The bacterial burden in the kidneys, spleens, and catheters were not significantly different between diabetic and nondiabetic rats.