Fig. 3.

Phylogenetic relationship between the major capsid proteins of the Alpha-7 and Alpha-9 genotypes. (A) Amino acid sequences of the L1 major capsid proteins representing both VLP and pseudoviruses of the Alpha-7 (HPV18, HPV39, HPV45, HPV59, HPV68) and Alpha-9 (HPV16, HPV31, HPV33, HPV35, HPV52, HPV58) genotypes and the control BPV [20]. Radial representation of NJ tree with branches having less than 80% bootstrap (n = 500 replicates) support (HPV35 and HPV59) indicated in gray. (B) Heatmap representation of inter-genotype genetic distances based upon external surface loops only or remaining (non-loop) backbone for the L1 proteins of the indicated Alpha-7 and Alpha-9 genotypes. Key indicates heatmap gradient.