Table 2.
Clinical details on patient B (Isolate MAL-1) throughout his hospital stay
| Day | BP (mmHg) | Hb (g/dL) | Plt (×10 3 /μl) | TSB (μmol/L) | AST (IU/L) | ALT (IU/L) | SCr (μmol/L) | Blood bacteriological & fungal culture | Anti-malarials | Antibiotics | Additional notes |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
1 |
102/55 |
12.4 |
65 |
16 |
47 |
39 |
100 |
N/A |
N/A |
N/A |
PR 60 BPM; SPO2 97% RA; loss of appetite; Lungs: clear |
|
2 |
92/52 |
N/A |
N/A |
N/A |
N/A |
N/A |
107 |
N/A |
Chloroquine |
N/A |
PR 70 BPM; Lungs: clear; |
| Primaquine |
Dengue IgM negative |
||||||||||
|
3 |
118/66 |
N/A |
107 |
13 |
88 |
71 |
112 |
N/A |
Chloroquine |
N/A |
PR 70 BPM; SPO2 98% RA; |
| Primaquine |
Lungs: minimal basal crepitations |
||||||||||
|
4 |
106/60 |
10.5 |
120 |
13 |
50 |
90 |
101 |
Negative |
Artesunate |
Ceftriaxone |
PR 66 BPM; Haemoptysis, epistaxis, shortness of breath; CXR: bilateral haziness |
| Quinine | |||||||||||
|
5 |
115/56 |
11.2 |
170 |
8 |
56 |
62 |
114 |
N/A |
Artesunate |
Ceftriaxone |
Blood smear: negative for malaria parasites; Transferred to ICU |
|
6 |
104/50 |
9.4 |
183 |
6 |
58 |
43 |
139 |
Negative |
Artesunate |
Tazocin® |
Blood smear: negative for malaria |
|
7 |
95/56 |
10.3 |
197 |
9 |
46 |
42 |
215 |
Negative |
Artesunate |
Tazocin® |
Blood smear: negative for malaria |
|
8 |
102/70 |
9.4 |
178 |
8 |
88 |
43 |
291 |
|
Artesunate |
Tazocin® |
Blood smear: negative for malaria; respiratory acidosis |
| Primaquine | |||||||||||
|
9 |
143/64 |
9.0 |
184 |
7 |
49 |
39 |
297 |
Negative |
Artesunate |
Tazocin® |
Blood smear: negative for malaria |
|
10 |
170/60 |
8.5 |
199 |
10 |
54 |
48 |
316 |
N/A |
Artesunate |
Tazocin® |
Blood smear: negative for malaria |
|
11 |
165/68 |
8.1 |
231 |
8 |
99 |
81 |
301 |
N/A |
N/A |
Tazocin® |
Ferritin blood test: 2,118 ng/ml |
|
12 |
200/78 |
8.1 |
288 |
13 |
128 |
148 |
309 |
Negative |
N/A |
Vancomycin |
|
| Imipenem | |||||||||||
|
13 |
160/60 |
6.8 |
311 |
16 |
137 |
190 |
392 |
N/A |
N/A |
Vancomycin |
Hemolysis screening: negative; |
| Imipenem |
CXR: worsening |
||||||||||
|
14 |
170/63 |
9.1 |
265 |
13 |
47 |
106 |
408 |
N/A |
N/A |
Vancomycin |
|
| Imipenem | |||||||||||
|
15 |
135/51 |
9.5 |
270 |
22 |
65 |
74 |
472 |
Positive for Enterobacter cloacae |
N/A |
Vancomycin |
Rigours; acidosis (resp. & met.) |
| Imipenem |
ABG: pH 7.128; pCO2 59.5 mmHg; |
||||||||||
| SLED 4 hours | |||||||||||
|
16 |
111/45 |
9.1 |
225 |
19 |
43 |
51 |
413 |
N/A |
N/A |
Vancomycin |
CVVHD |
| Imipenem | |||||||||||
|
17 |
134/57 |
7.5 |
179 |
29 |
109 |
65 |
424 |
N/A |
N/A |
Vancomycin |
Seizures; SLED 8 hours |
| Meropenem | |||||||||||
|
18 |
135/55 |
7.3 |
178 |
30 |
38 |
40 |
320 |
N/A |
N/A |
Meropenem |
Gentle HD 4 hours |
|
19 |
130/56 |
9.0 |
204 |
34 |
40 |
30 |
404 |
N/A |
N/A |
Meropenem |
Gentle HD 4 hours |
|
20 |
147/61 |
8.6 |
207 |
25 |
43 |
26 |
403 |
N/A |
N/A |
Meropenem |
Severe resp. acidosis; met. acidosis; gentle HD 4 hours |
|
21 |
140/54 |
N/A |
N/A |
N/A |
N/A |
N/A |
427 |
N/A |
N/A |
Meropenem |
Gentle HD 3 hours |
|
22 |
102/48 |
9.3 |
166 |
39 |
296 |
119 |
401 |
N/A |
N/A |
Meropenem |
Worsening hypoxia; hypotensive; Gentle HD 6 hours |
| 23 | N/A | N/A | N/A | 22 | 136 | 109 | 314 | N/A | N/A | N/A | Asystole; death |
N/A = not available; BP = blood pressure; Hb = haemoglobin; Plt = platelet; TSB = total serum bilirubin; AST = aspartate aminotransferase; ALT = alanine aminotransferase; SCr = serum creatinine; BP = blood pressure; BPM = beats per minute; PR = pulse rate; SPO2 = blood oxygen saturation; RA = room air; IgM = immunoglobulin M; CXR = chest X-ray; ICU = intensive care unit; resp. = respiratory; met. = metabolic; ABG = arterial blood gas; pCO2 = partial pressure of carbon dioxide; SLED = sustained low efficiency dialysis; CVVHD = continuous veno-venous haemodialysis; HD = haemodialysis.