Table 3.
SNPs selected for analysis
| NCBI SNP Reference | Cytogenetic Band | Gene a | Reference |
|---|---|---|---|
| rs17468277 |
2q33.1 |
ALS2CR12 (synonymous) (CASP8)b |
[35] |
| rs13387042 |
2q35 |
intergenic |
[32,33] |
| rs889312 |
5q11.2 |
MAP3K1 (upstream) |
[8,33] |
| rs10941679 |
5p12 |
intergenic |
[8,34] |
| rs2736098 |
5p15.33 |
TERT (synonymous) |
[31] |
| rs13281615 |
8q24.21 |
intergenic |
[8,33] |
| rs3731249 |
9p21.3 |
CDKN2A (missense; A148T) |
[37], CO-Ic |
| rs1219648 |
10q26 |
FGFR2 (intron) |
[30] |
| rs2981582 |
10q26 |
FGFR2 (intron) |
[8,33] |
| rs3817198 |
11p15.5 |
LSP1 (intron) |
[8] |
| rs766173 |
13q13.1 |
BRCA2 (missense; N289H) |
CO-I |
| rs1799944 |
13q13.1 |
BRCA2 (missense; N991D) |
[36], CO-I |
| rs28897710 |
13q13.1 |
BRCA2 (missense; T598A) |
CO-I |
| rs3803662 |
16q12.1 |
TOX3/LOC643714 (between) |
[8,32,33] |
| rs243865 |
16q13-q21 |
MMP2 (promoter) |
[29] |
| rs152451 | 16p12.2 | PALB2 (missense; Q559R) | CO-I |
a/NCBI ID of genes localized in proximity to the SNPs of interest (source: HapMap).
b/SNP rs17468277 is in strong LD (r2 = 1) with rs1045485 in CASP8 (D302H).
c/SNP selected based on the date provided by Genetic Counseling of Cancer Center and Institute of Oncology (CO-I) in Warsaw.