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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Gastroenterology. 2013 Nov 1;146(2):539–49.e7. doi: 10.1053/j.gastro.2013.10.059

Fig. 1. Hepatocyte-specific deletion of SIRT1 in mice increases susceptibility to developing fasting-induced fatty liver.

Fig. 1

A. Representative immunoblots for SIRT1 in two mouse livers from each group are shown. The expected deletion mutant protein in SIRT1 LKO mice, which migrates slightly faster than WT SIRT1, was visualized by immunoblotting. B. Blood glucose and plasma insulin levels in WT and SIRT1 LKO mice at 6- and 7-months of age that were fed a normal diet (Fed) or fasted for 24 h (Fasted) (n = 10-18). C. Plasma triglyceride and cholesterol levels in mice (n = 4-6). D and E. Hepatic steatosis was assessed by Oil Red O staining and quantified by measuring Oil Red O stained areas. F. Hepatic triglyceride and cholesterol levels in WT and SIRT1 LKO mice (n=4-6). Results are presented as the mean ± S.E.M. *P<0.05, vs. the fed WT mice; #P<0.05, vs. the fasted WT mice.