Table 7.
Pharmacokinetic parameters of BB, GA, GB, and GC following a single oral administration of GBTs to rats
| Analyte | C max (ng/ml) | T max (h) | AUC0–t (ng/(ml·h)) | AUC0–INF (ng/(ml·h)) | T 1/2 (h) | MRT (h) |
| BB | 40.62±20.53 | 2.08±1.81 | 303.02±66.64 | 346.69±104.26 | 3.58±1.86 | 5.65±2.60 |
| GA | 130.10±39.73 | 1.15±0.42 | 1125.74±283.31 | 1243.46±386.35 | 3.66±1.20 | 7.15±3.46 |
| GB | 38.88±19.77 | 0.92±0.49 | 428.37±134.55 | 457.32±148.72 | 4.60±2.80 | 6.72±2.32 |
| GC | 9.36±1.85 | 3.20±1.89 | 132.44±63.55 | 140.48±61.59 | 5.48±0.86 | 8.52±1.50 |
Data are presented as mean±SD, n=5. BB: bilobalide; GA: ginkgolide A; GB: ginkgolide B; GC: ginkgolide C; C max: peak concentration; T max: peak time; AUC0–t: area under the curve from 0 h to t h; AUC0–INF: area under the curve from 0 h to infinite; T 1/2: half-life; MRT: mean residence time