Table 8.
Pharmacokinetic parameters of QCT, KMF, and ISR following a single oral administration of GBTs to rats
| Analyte | C 1max (ng/ml) | C 2max (ng/ml) | T 1max (h) | T 2max (h) | AUC0–t (ng/(ml·h)) | AUC0–INF (ng/(ml·h)) | T 1/2 (h) | MRT (h) |
| QCT | 26.40±5.74 | 13.45±6.60 | 0.22±0.19 | 11.50±11.54 | 285.04±78.20 | 444.80±174.77 | 26.74±9.38 | 45.48±11.10 |
| KMF | 12.26±2.37 | 14.81±7.54 | 0.18±0.18 | 9.00±8.49 | 297.22±209.13 | 552.27±283.01 | 14.23±3.38 | 29.70±6.19 |
| ISR | 11.55±4.93 | 21.04±8.40 | 0.25±0.23 | 12.00±11.02 | 704.86±328.49 | 978.37±465.73 | 22.46±2.00 | 37.29±5.18 |
Data are presented as mean±SD, n=5. QCT: quercetin; KMF: kaempferol; ISR: isorhamnetin; C max: peak concentration; T max: peak time; AUC0–t: area under the curve from 0 h to t h; AUC0–INF: area under the curve from 0 h to infinite; T 1/2: half-life; MRT: mean residence time