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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Free Radic Biol Med. 2014 May 14;73:201–213. doi: 10.1016/j.freeradbiomed.2014.04.029

Figure 7. Cav-1 knockout mice exhibit increased Nox2 and Nox4 mRNA and protein expression and increased pulmonary hypertension.

Figure 7

(A) Protein expression of Nox2 and Nox4 in whole lung lysates from WT or Cav-1−/− mice exposed to hypoxia was determined by Western blot. (B) Nox2 and Nox4 mRNA expression were determined by qRT-PCR (ΔΔCt) normalized to GAPDH in lung tissue from WT or Cav-1−/− mice exposed to hypoxia. *different from wild type, p < 0.05 (n = 3). (C) Hypoxia-induced PH is enhanced in Cav1−/− mice, * versus normoxia, + versus WT p<0.05 (n=3–5).