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. 2014 Nov 12;8:387. doi: 10.3389/fnbeh.2014.00387

Figure 3.

Figure 3

The fear conditioning deficit observed in progeny from VPA-Hi exposed dams is likely not due to deficits in sensory modalities necessary for auditory fear conditioning. (A) Thermal nociception as measured by the hotplate test did not differ between progeny from VPA-Lo and saline exposed dams (Saline = 12, VPA-Lo = 12) (B) or progeny from VPA-Hi and saline exposed dams (Saline = 12, VPA-Lo = 11) (C) Response to foot shock stimuli did not differ between progeny from VPA-Lo and saline exposed dams (Saline = 10, VPA-Lo = 10) (D) or progeny from VPA-Hi and saline exposed dams (Saline = 12, VPA-Lo = 11). (E) The primary auditory cortex response strength and response latency to a 5 kHz tone did not differ between progeny from VPA-Hi and saline exposed dams (Saline = 10, VPA-Hi = 10). (F) Hearing ability to a 5 kHz, 0–75dB tone did not differ between progeny from VPA-Hi and saline exposed dams (Saline = 10, VPA-Hi = 10) as measured by auditory cortex neuronal spike firing upon exposure to 5 kHz, 0–75 dB tones. Data presented as mean ± s.e.m.