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. 2014 Nov 12;8:384. doi: 10.3389/fnbeh.2014.00384

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Copyright © 2014 Petravicz, Boyt and McCarthy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Morris water maze for learning and memory are unaffected in the IP3R2 cKO. (A) Training for the visually identified location of the escape platform was not significantly different (p = 0.08) between IP3R2 cKO mice (clear circles, n = 46) and control mice (solid circles, n = 53). (B) Hidden platform training over the course of 6 days showed that IP3R2 cKO mice displayed no significant difference in acquisition of the location of hidden platform compared to controls (p = 0.92). (C) Reversal of acquisition and acquisition of the relocated platform location training over the course of 6 days displays no significant difference between IP3R2 cKO and controls (p = 0.97). (D) Both IP3R2 cKO and control mice present a significant preference (IP3R2 cKO, p ≤ 0.0001; control p < 0.0001) for the target quadrant (Q1) in the probe trial of the hidden platform acquisition task. Direct comparison of Q1 preference is not significantly different (p = 0.57) between the two groups. (E) Both IP3R2 cKO (p < 0.0001) and control mice (p < 0.0001) display a significant preference for the target quadrant (Q3) in the probe trial of the reversal hidden platform task. Direct comparison of Q3 preference is also not significantly different (p = 0.99) between the two groups. Error bars indicate s.e.m. ^*** p < 0.001.