Table 3. The Frequency of Symptom Score in Different Cycles, and the Effects of Interventional Groups and Cycles Using Repeated-Measure Analysis of Variance .

	Cycle 1	Cycle 2	Cycle 3	Cycle 4
The frequency of symptom score, mean (SD)
Intervention	84.13 (40.6)	79.3 (51.1)	61 (47.6)	56.5 (43.2)
Placebo	79 (34.3)	73.2 (41.8)	58 (46.2)	52.5 (42.6)
The cycles
F	8.61
P value			0.0001
Frequency of total symptom score in cycles × Interventional group
F	1.13
P value			0. 35