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. Author manuscript; available in PMC: 2014 Nov 12.
Published in final edited form as: Mol Cells. 2009 Jul 20;28(1):1–5. doi: 10.1007/s10059-009-0109-9

Fig. 2. Schema for potential functions of PKD1 in VEGF-induced angiogenesis.

Fig. 2

VEGF-activated PKD1 phosphorylates class IIa HDACs (HDAC 5 and 7) and induces those cytoplasmic accumulations in endothelial cells. Eventually, VEGF-induced PKD1 pathway is involved in VEGF-induced gene expressions, EC migration, tube formation and microvessel sprouting.