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. Author manuscript; available in PMC: 2014 Nov 12.
Published in final edited form as: Curr Opin Cell Biol. 2012 Nov 21;25(1):92–98. doi: 10.1016/j.ceb.2012.10.012

Figure 1. Endosome trafficking and ESCRT mediated scission of the ICB are required for the completion of cytokinesis.

Figure 1

A model describing the two different mechanisms proposed to regulate the final abscission step in cytokinesis. In late cytokinesis, an actin stabilized intracellular bridge contains three types of endosomes that are known to localize to the intracellular bridge: FIP3-endosomes (Green), Rab35-endosomes (Red) or PI3P-enriched endosomes (Blue). Endosomes mediate ICB actin depolymerization and formation of the secondary ingression to narrow the bridge to ~100 nm. This thinner bridge now is recognized by CHMP4B which marks the abscission site and severs the plasma membrane to complete cytokinesis. The final membrane scission step by occurs through the action of CHMP4B (ESCRT-III).