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. Author manuscript; available in PMC: 2014 Nov 12.
Published in final edited form as: Part Part Syst Charact. 2014 Jun 16;31(11):1141–1150. doi: 10.1002/ppsc.201400036

Figure 2.

Figure 2

HDL NPs stabilize conjugated ONs to nuclease degradation and RNAi-HDL NPs regulate in vitro VEGFR2 expression. (a) NS ONs mixed with HDL NPs or free in solution were exposed to RNAse A for different time intervals (0, 10, 20, and 30 mins). Reactions were stopped and reaction contents were subjected to polyacrylamide gel electrophoresis and stained with ethidium bromide. (b) RT-qPCR (plot) and Western blotting demonstrate knockdown of VEGFR2 mRNA and protein, relative to ß-actin mRNA and protein levels, respectively, after treatment with RNAi-HDL NP (RNAi-HDL) or positive control Lipofectamine/RNAi (LIP+RNAi).