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. Author manuscript; available in PMC: 2015 Jan 17.
Published in final edited form as: Circ Res. 2014 Jan 17;114(2):368–378. doi: 10.1161/CIRCRESAHA.113.300536

Figure 3. Schematic model showing SIRT6-depdendent transcriptional regulation of IGF/Akt signaling-related genes.

Figure 3

Under basal conditions SIRT6 binds to chromatin as a complex with c-jun and deacetylates histones (H3K9), leading to chromatin condensation and repression of the IGF/Akt signaling-related genes. Under pathological stress, SIRT6 levels are reduced leading to increased acetylation of H3K9 at the promoters of IGF/Akt signaling related genes and c-jun mediated transcriptional activation. IGF/Akt signaling related genes which are activated in SIRT6KO hearts are shown on the right side of the figure (For details see ref 34).