Table 3.
Outcomes of patients with antipsychotic medication for delirium
| Total (n = 2453) | Risperidone (n = 835) | Quetiapine (n = 779) | Perospirone (n = 88) | Olanzapine (n = 87) | Aripiprazole (n = 61) | Haloperidol (n = 480) | Others (n = 123) | |
|---|---|---|---|---|---|---|---|---|
| Maximum dose, mg/day | 1.35 (0.96) | 71.8 (87.5) | 8.09 (5.27) | 10.2 (11.1) | 7.23 (7.03) | 6.40 (5.05) | ||
| CGI-Ia | 2.02 (1.09) | 2.13 (1.10) | 1.74 (0.96) | 1.85 (0.89) | 1.93 (1.05) | 2.16 (1.33) | 2.32 (1.16) | 2.02 (1.09) |
| Duration of delirium, n (%) | ||||||||
| ≤1 weekb | 1332 (54) | 411 (49) | 471 (60) | 49 (56) | 58 (67) | 26 (43) | 249 (52) | 68 (55) |
| ≤2 weeks | 520 (21) | 210 (25) | 147 (19) | 17 (19) | 15 (17) | 15 (25) | 92 (19) | 24 (20) |
| >2 weeks | 601 (25) | 214 (26) | 161 (21) | 22 (25) | 14 (16) | 20 (33) | 139 (29) | 31 (25) |
| Course, n (%) | ||||||||
| Return homec | 1249 (51) | 456 (55) | 405 (52) | 39 (44) | 39 (45) | 26 (43) | 227 (47) | 57 (46) |
| Institutionalization | 695 (28) | 222 (27) | 261 (34) | 31 (35) | 25 (29) | 18 (30) | 95 (20) | 43 (35) |
| Deathd | 386 (16) | 108 (13) | 79 (10) | 12 (14) | 21 (24) | 11 (18) | 139 (29) | 16 (13) |
| In hospital | 123 (5.0) | 49 (5.9) | 34 (4.4) | 6 (6.8) | 2 (2.3) | 6 (9.8) | 19 (4.0) | 7 (5.7) |
Data represent mean (SD) or n (%), unless otherwise indicated. CGI-I, Clinical Global Impressions—Improvement Scale.
a
Kruskal–Wallis test revealed significant difference in age between the groups (p < 0.0001).
b
The rate of delirium within one week was significantly higher in patients with olanzapine than in other patients (p = 0.025).
c
The rate was significantly higher in patients with risperidone than in other patients (p = 0.0097).
d
All death were related to aggravation of previous physical condition. The rate was significantly higher in patients with haloperidol than in other patients (p < 0.0001).