Table 5.
Serious adverse events and extrapyramidal symptoms during antipsychotic medication for delirium
| Total (n = 2453) | Risperidone (n = 835) | Quetiapine (n = 779) | Perospirone (n = 88) | Olanzapine (n = 87) | Aripiprazole (n = 61) | Haloperidol (n = 480) | Others (n = 123) | |
|---|---|---|---|---|---|---|---|---|
| Serious adverse event, n (%)a | 22 (0.9) | 8 (1.0) | 5 (0.6) | 0 (0) | 2 (2.3) | 0 (0) | 5 (1.0) | 3 (2.4) |
| Aspiration pneumonia | 17 (0.7) | 7 (0.8) | 4 (0.5) | 0 | 2 (2.3) | 0 | 3 (0.6) | 1 (0.8) |
| Cardiovascular event | 4 (0.2) | 1 (0.1) | 1 (0.1) | 0 | 0 | 0 | 0 | 2 (1.6) |
| Fractures due to falls | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Intracranial injury due to falls | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Venous thromboembolism | 1 (0.0) | 0 | 0 | 0 | 0 | 0 | 1 (0.2) | 0 |
| Others | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Extrapyramidal symptoms | ||||||||
| Rate, n (%)b | 137 (5.6) | 53 (6.3) | 34 (4.4) | 8 (9.1) | 4 (4.6) | 2 (3.3) | 30 (6.3) | 6 (4.9) |
| Severity (DIEPSS), median | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
Data represent mean (SD) or n (%), unless otherwise indicated. DIEPSS, Drug-induced Extrapyramidal Symptom Scale.
a
There was no significant difference in the rate between the groups (p = 0.40).
b
There was no significant difference in the rate between the groups (p = 0.22).