Table 3. Xenobiotic response elements upstream of C. teleta CYPs.

CYP	Number of XREs 10 kb upstream
CYP331A1*	3
CYP331A2	0
CYP331A3	0
CYP331B1	1
CYP4V25	2
CYP4AT1*	1
CYP4BK4	4
CYP4EE1	0
CYP3060A1	1
CYP3061A1	1

Each gene was searched for the consensus xenobiotic response element (XRE) sequence TNGCGTG [39], 10 kb upstream of the start site. Genes were chosen based on homology to vertebrate CYP1s and genes from clan 3 and 4. Genes were searched in the 10 kb upstream region. The asterisks mark the genes which were transcriptionally upregulated with exposure to the PAHs benzo[α]pyrene, 3-methylcholanthrene, or fluoranthene [18]. p-value of 5.96e−05 and q-value of 1 for all sites.