Table 1. The lowest stimulatory concentrations of pyridines that induced larvae of C. teleta to metamorphose compared with the KM of these same chemicals on the pyridine-activated ion channel of the crayfish A. torrentium.
Species | ||
Chemical | C. teleta | A. torrentium |
Pyrazinecarboxamide | 1 µM | 1.5 µM |
Nicotinamide | 3 µM | 10 µM |
Nicotinic acid | 1 mM | >1 mM |
4-acetylpyridine | 200 µM | 70 µM |
The concentration of 4-acetylpyridine that inhibited 50% of the larvae of C. teleta is also compared with the IC50 of 4-acetylpyridine for the crayfish (adapted from Hatt and Schmiedel-Jacob, 1984).