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. 2014 Nov 12;9(11):e109535. doi: 10.1371/journal.pone.0109535

Table 1. The lowest stimulatory concentrations of pyridines that induced larvae of C. teleta to metamorphose compared with the KM of these same chemicals on the pyridine-activated ion channel of the crayfish A. torrentium.

Species
Chemical C. teleta A. torrentium
Pyrazinecarboxamide 1 µM 1.5 µM
Nicotinamide 3 µM 10 µM
Nicotinic acid 1 mM >1 mM
4-acetylpyridine 200 µM 70 µM

The concentration of 4-acetylpyridine that inhibited 50% of the larvae of C. teleta is also compared with the IC50 of 4-acetylpyridine for the crayfish (adapted from Hatt and Schmiedel-Jacob, 1984).