Skip to main content
. 2014 Nov 12;9(11):e110040. doi: 10.1371/journal.pone.0110040

Figure 3. NLGP mediated normalization of angiogenesis is absent in immunocompromised mice.

Figure 3

Schematic presentation of NLGP prophylaxis in A.1. normal mice, A.2. and A.3. cyclosporine treated/immunocompromised and A.4. athymic nude mice. B.1.-B.4. Representative photographs of murine tumors with B.1. PBS, NLGP, B.2. NLGP-Cyclosporin pretreatment, B.3. NLGP pretreatment with adoptive transfer of immune cells and B.4. NLGP and PBS pretreatment (athymic nude mice). C.1.-C.4. Tumor growth curve presenting Mean ± SD. *p<0.001, **p<0.01, in comparison to NLGP group with other above mentioned group and D.1.-D.4. Angiogenic profile of mice with D.1. PBS, NLGP, D.2. NLGP-Cyclosporin pretreatment, D.3. NLGP pretreatment with adoptive transfer of immune cells and D.4. NLGP and PBS pretreatment (athymic nude mice). E. Immunohistochemical detection of VEGF, VEGFR2 and CD31 in tumor sections as mentioned in A.1–A.3.