Figure 1. Anti-Abeta compounds are ligands for sigma-2/PGRMC1 receptor.

A, CT0109, CT0093, CT01344 and CT01346 displace the fiduciary sigma-2 ligand [³H]-DTG from receptors on human B cell lines. B. Autoradiograms of 18.4 nM [¹²⁵I]RHM-1 binding to human frontal cortex slices in the presence of 10, 100, 1000, 10,000 nM of CT0109 and CT0093, N = 4. Color bar under images show false coloring scale. [¹²⁵I]RHM-1 displays specific saturable binding to human frontal cortex tissue as assessed by quantitative autoradiography in dose-response format (C) and as a Scatchard plot (D). E. Dose response curves for data obtained from autoradiograms in B. The Ki's for CT0109 and CT0093 at the [¹²⁵I]RHM-1 binding site were 57±23 nM and 33±12 nM, respectively.