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. 2014 Nov 12;9(11):e111899. doi: 10.1371/journal.pone.0111899

Figure 3. Abeta oligomer treatment causes progressive upregulation of sigma-2/PGRMC1 expression.

Figure 3

Expression of sigma-2/PGRMC1 in the cell body of the entire culture cell population significantly increases with time of exposure to Abeta oligomers (A, C, E, 400 nM Abeta oligomers, *p = 0.05, ***p = 0.001, Student's t-test, N>1500 neurons and glia per condition) compared to vehicle-treated cultures (B, D, F). All scale bars  = 20 microns. G. Immunofluorescent intensity of sigma-2/PGRMC1 in Abeta oligomer-treated cells, relative to vehicle treatment, at 1 hr, 24 hr and 48 hr.