Figure 7. Antibodies and compounds directed against sigma-2/PGRMC1 dose-dependently displace endogenous human Abeta oligomers from specific tissue locations in Alzheimer's brain neocortical tissue sections.

A, Abeta oligomers located in a 2 micron halo surrounding compact thioflavin-S positive plaques is displaced from frozen postmortem human AD brain tissue sections (N = 7 patients) by C-terminal sigma-2/PGRMC1 antibody and receptor antagonist CT01344 (B) in a dose-dependent manner compared to vehicle-treated brain sections from the same individual (Spearman's rank order, rho  = −0.492, p = 0.038). All scale bars  = 20 microns. See Fig. S4 for details on quantification method.