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. 2014 Nov 12;9(11):e112430. doi: 10.1371/journal.pone.0112430

Figure 2. Rare protein-altering variants in TSHZ3 in the Georgia Centenarian cohort versus NHLBI cohort.

Figure 2

To see if TSHZ3 is enriched for rare protein-altering variants in long-lived individuals, Sanger sequencing was performed on TSHZ3 in 99 Caucasians with extreme longevity (age 98–105). There was not a significant enrichment comparing the allele frequency of all rare protein-altering variants in the centenarians (4.0%; black bar) to 4300 Caucasian controls from the NHLBI exome project (2.5%; white bar). Both cohorts were annotated for protein-altering variants and filtered against 1000G EUR (MAF<0.015).