Table 3. Protein-altering variants in TSHZ3 in Georgia Centenarian cohort.
Position on Chr19 | Ref/Var | AA Pos | AA1/AA2 | Supercent | Cent | Nona | 1000G EUR MAF |
31769738 | G/A | 321 | R/W | 0 | 1 | 0 | novel |
31769366 | C/T | 445 | V/M | 1 | 0 | 0 | 0.0013 |
31769293 | T/C | 469 | E/G | 1 | 2 | 1 | 0.01 |
31769021 | T/C | 560 | M/V | 0 | 1 | 0 | novel |
31768639 | G/A | 687 | P/L | 1 | 0 | 0 | novel |
31768594 | A/C | 702 | L/W | 0 | 0 | 1 | novel |
31768267 | G/A | 811 | T/M | 0 | 1 | 0 | novel |
31768178 | C/T | 841 | E/K | 1 | 0 | 0 | novel |
31767599 | C/T | 1034 | E/K | 0 | 1 | 0 | novel |
Position (bp) on chromosome 19 (Chr19) of variant, reference (Ref) and Variant (Var) allele, Amino Acid (AA) position, AA1 (ref), AA2 (var), Supercentenarian carriers (shown for reference), Centenarians carriers, Nonagenarians carriers, Minor allele frequency (MAF) in 1000G EUR.