Table 2. Correlation of activation of innate response genes with fungal and bacterial infection, and neutrophils in the lung interstitium, and fungal hyphae and bacterial scores in wing tissues.
Correlate | IL23 | Cathelicidin | IL10 | TNF | |||||
GAPDH | CytB | GAPDH | CytB | GAPDH | CytB | GAPDH | CytB | ||
Infection | Correlation (r) | −0.60 | −0.55 | −0.67 | −0.49 | −0.72 | −0.75 | −0.71 | −0.77 |
Significance (P) | <0.001 | 0.001 | <0.001 | 0.001 | 0.018 | 0.008 | 0.004 | 0.001 | |
N | 30 | 30 | 45 | 45 | 10 | 11 | 14 | 14 | |
Ave. hyphae score | Correlation (r) | −0.67 | −0.60 | −0.64 | −0.42 | −0.71 | −0.69 | −0.57 | −0.60 |
Significance (P) | <0.001 | <0.001 | <0.001 | 0.004 | 0.02 | 0.018 | 0.033 | 0.024 | |
N | 30 | 30 | 45 | 45 | 10 | 11 | 14 | 14 | |
Ave. bacterial score | Correlation (r) | −0.77 | −0.65 | −0.61 | −0.42 | −0.69 | −0.61 | ||
Significance (P) | <0.001 | <0.001 | <0.001 | 0.004 | 0.026 | 0.046 | NS | NS | |
N | 30 | 30 | 45 | 45 | 10 | 11 | 14 | 14 | |
Lung Interstitial neutrophil score | Correlation (r) | −0.65 | −0.64 | −0.35 | −0.45 | ||||
Significance (P) | 0.001 | 0.001 | 0.036 | 0.005 | NS | NS | NS | NS | |
N | 22 | 22 | 37 | 37 | 10 | 11 | 14 | 14 | |
Pearson's coefficients were calculated for the ΔCt levels for cytokine transcripts for bats in each treatment class and lung interstitial neutrophil scores and mean bacterial and hyphae scores for 5 wing sections for each bat.
N = number of samples with usable Ct values. NS = not significant.