Figure 6. T2 imaging and histology of the mdx leg.

Additional mice were assayed by T2 imaging at 6 months of age, followed by immediate collection of the whole leg for histology. A) Representative T2 images are provided of mdx (top two rows) and wild-type (bottom row) mice. The region of interest outlined in white is shown enlarged in (B). C) H&E stained cross section images corresponding to MRI slices in panels A and B. A montage image of the full leg is provided, with the inset area displayed in (D) at higher magnification (Rectangles in B and C represent the approximate areas presented in higher magnification images in D; Scale bars  = 2 mm in C and 0.5 mm in D).