Table 1. Statistical sample size calculations to detect intervention effects in mdx mice.
| Values at 6 weeks of age | |||||
| Method | Measure | Site | WT mean ±SD | mdx mean ±SD | N per group to detect a 20% change in mdx |
| 31P NMR Spec | PCr: tATP | 0.585±0.030 | 0.438±0.047 | 4 | |
| T2 | % elevated signal | Leg | 4±2 | 21±3 | 8 |
| Vol. elevated (mm3) | Leg | 4.16±1.36 | 22.91±3.31 | 7 | |
| % elevated signal | Thigh | 7±1 | 22±5 | 13 | |
| Vol. elevated (mm3) | Thigh | 7.52±0.75 | 30.89±7.33 | 18 | |
| Fat Suppression | % elevated signal | Leg | 1±1 | 9±3 | 41 |
| Vol. elevated (mm3) | Leg | 0.70±0.49 | 10.00±3.55 | 39 | |
| % elevated signal | Thigh | 1±1 | 17±6 | 39 | |
| Vol. elevated (mm3) | Thigh | 1.69±0.73 | 23.34±9.04 | 58 | |
Abbreviations: NMR Spec, Nuclear Magnetic Resonance spectroscopy; PCr, phosphocreatine; tATP, total adenosine triphosphate; Vol., Volume; WT, wild-type.