Table 3. Mean differences in mJSW change over 4 years at minimum mJSW among the mitochondrial DNA (mtDNA) haplogroups in 216 OA patients.

	JSN knees (N = 216)			No-JSN knees (N = 216)
mtDNA haplogroups	Mean change±SD	SRM	p-value#	Mean change±SD	SRM	p-value#
H (N = 87)	−0.52±0.68	−0.77	0.688	−0.56±1.07	−0.52	0.754
J (N = 24)	−0.75±0.86	−0.87	0.217	−0.62±0.78	−0.79	0.578
T (N = 24)	−0.56±0.77	−0.73	0.919	−0.14±0.37	−0.39	0.034*
Uk (N = 44)	−0.53±0.68	−0.77	0.995	−0.61±1.12	−0.59	0.336
Others (N = 37)	−0.48±0.68	−0.71	0.662	−0.45±0.65	−0.69	0.886

Data are mean±standard deviation, in millimetres (mm); mJSW: medial joint space width; JSN: joint space narrowing; SD: standard deviation; SRM: standardized response means (mean divided by SD); (#) multivariate (ANCOVA) analysis, adjusting for gender, age and body mass index (BMI) at baseline; (*) indicates statistical significance at p≤0.05.