Table 1.
Proteins orthologue to A. salmonicida T3SS components
| T3SS part | Information | Ysc Family | Ssa/Esc Family | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Aeromonas | Photorhabdus | Yersinia | Vibrio | Pseudomonas | Bordetella | Salmonella | Shigella | ||
| Translocon | Pore | AopB | LopB | YopB | VopB | PopB | BopB | SipB | IpaB |
| Pore | AopD | LopD | YopD | VopD | PopD | BopD | SipC | IpaC | |
| Chaperone | AcrH | LssH | SycD/LcrH | VcrH | PcrH | BcrH1 | SicA | LpgC | |
| Needle | Tip | AcrV | LssV | LcrV | VcrV | PcrV | Bsp22 | SipD | IpaD |
| Chaperone | AcrG | LssG | LcrG | VcrG | PcrG | – | – | – | |
| Body | AscF | LscF | YscF | VscF | PscF | BscF | PrgI | MxiH | |
| Chaperone | AscG | LscG | YscG | VscG | PscG | – | – | – | |
| Chaperone | AscE | LscE | YscE | VscE | PscE | BscE | – | – | |
| Chaperone | AcrR | LssR | LcrR | VcrR | PcrR | – | – | – | |
| Polymerization control | AscH | LscH | YscH/YopR | VscH | PscH | – | – | – | |
| Length control | AscP | LscP | YscP | VscP | PscP | BscP | InvJ | Spa32 | |
| Base | OM ring | AscC | LscC | YscC | VscC | PscC | BscC | InvG | MxiD |
| Chaperone | AscW/ExsB | LscW | YscW | VscW | ExsB | – | – | – | |
| Inner rod | AscI | LscI | YscI | VscI | PscI | BscI | PrgJ | MxiI | |
| IM ring ext | AscD | LscD | YscD | VscD | PscD | BscD | PrgH | MxiG | |
| IM ring int | AscJ | LscJ | YscJ | VscJ | PscJ | BscJ | PrgK | MxiJ | |
| C-ring, socket/Cup | AscR | LscR | YscR | VscR | PscR | BscR | SpaP | Spa24 | |
| C-ring, socket/Cup | AscS | LscS | YscS | VscS | PscS | BscS | SpaQ | Spa9 | |
| C-ring, socket/Cup | AscT | LscT | YscT | VscT | PscT | – | SpaR | Spa29 | |
| C-ring, socket/Cup | AscU | LscU | YscU | VscU | PscU | BscU | SpaS | Spa40 | |
| C-ring, socket/Cup | AscV | LssD | YscV | VcrD | PcrD | BcrD | InvA | MxiA | |
| C-ring, secretion specificity | AscX | LssB | YscX | VscX | PscX/Pcr3 | – | – | – | |
| C-ring, secretion specificity | AscY | LssC | YscY | VscY | PscY/Pcr4 | Bcr4 | – | – | |
| ATPase | AscN | LscN | YscN | VscN | PscN | BscN | InvC | Spa47 | |
| Cytoplasmic | AscK | LscK | YscK | VscK | PscK | BscK | OrgA | MxiK | |
| Cytoplasmic | AscL | LscL | YscL | VscL | PscL | BscL | OrgB | MxiN | |
| Cytoplasmic | AscQ | LscQ | YscQ | VscQ | PscQ | BscQ | SpaO | Spa33 | |
| Regulators | Secretion | AopN | LopN | YopN | VopN | PopN | BopN | InvE | MxiC |
| Secretion | Acr1 | LssA | TyeA | Vcr1 | Pcr1 | – | – | – | |
| Secretion | AscB | LscB | YscB | VscB | PscB | – | – | – | |
| Secretion | Acr2 | LssN | SycN | Vcr2 | Pcr2 | – | – | – | |
| Substrate recycling? | AscO | LscO | YscO | VscO | PscO | BscO | InvI | Spa13 | |
| T3SS transcription | ExsA/AscA | LscA | LcrF | ExsA | ExsA | – | – | – | |
| T3SS transcription | ExsC | LscY | – | ExsC | ExsC | – | – | – | |
| T3SS transcription | ExsD | LscZ | – | ExsD | ExsD | – | – | – | |
| T3SS transcription | ExsE | ExsE | – | ExsE | ExsE | – | – | – | |
| Effectors | ADP-ribosylase + GAP | AexT | – | YopE | VopT | ExoT+ExoS | – | – | – |
| Chaperone | SycE | Plu3789 | SycE/YerA | – | CesT+CesT | – | – | – | |
| Phosphotyrosine phosphatase | AopH | – | YopH | – | – | – | – | – | |
| Chaperone | SycH | – | SycH | – | – | – | – | – | |
| Inositol Phosphatase | Ati2 | plu4615 | – | VPA0450 | – | – | – | – | |
| Chaperone | Ati1 | Plu4614 | – | VPA0451 | – | – | – | – | |
| Serine/threonine kinase | AopO | – | YopO/YpkA | – | – | – | – | – | |
| Chaperone | SycO | – | SycO | – | – | – | – | – | |
| NF-κB inhibition + apoptosis | AopP | – | YopJ/YopP | VopA/P | – | – | AvrA | – | |
| Lipid rafts? | AopX | Plu4750 | – | VopR | – | BteA | – | – | |
| Chaperone | SycX | – | – | – | – | – | – | – | |
| AMPylation | AopS | – | – | VopS/VepB | – | – | – | – | |
| Chaperone | SycS | – | – | VPA0451 | – | – | – | – | |
| Hydrolase | ASA_P5G088 ? | – | – | VP1677, −1678 | – | – | – | – | |