Figure 8. BAPTA/TG-induced SOC currents are mediated by CRAC channels in dorsal horn neurons.

A and B, BAPTA/TG-induced calcium currents recorded with the gap-free protocol (A) and with a ramp protocol (B). C, effect of replacing 10 mm Ca²⁺ with 10 mm Ba²⁺ on BAPTA/TG-induced current recorded with the gap-free protocol. Left, a representative BAPTA/TG-induced current recorded in 10 mm Ca²⁺ or 10 mm Ba²⁺; right, summary of BAPTA/TG-induced Ca²⁺ current and Ba²⁺ current (n = 9 neurons). D, effect of replacing 2 mm Ca²⁺ with 2 mm Ba²⁺ on TG-induced SOCE. Left, representative TG-induced Ca²⁺ or Ba²⁺ entry; right, summary of TG-induced Ca²⁺ entry (n = 52 neurons) and Ba²⁺ entry (n = 40 neurons). Arrows indicate where current amplitudes were measured. Values represent mean ± SEM; *P < 0.05, compared by Student's t test.