Figure 10. Carbachol evokes sIPSCs from both WT and PV-M₁KO mice.

Representative response to carbachol (5 μm) application in (A) WT mice and (B) PV-M₁KO mice (raw traces displayed). Population data showing the change of sIPSC in (C) amplitude and (D) frequency in response to carbachol application in WT mice (paired t test, t₆ = 2.75, P = 0.0328; t₆ = 5.3, P = 0.0018, n = 7, respectively), and in PV-M₁KO mice (Wilcoxon matched pairs signed rank test, W₅ = 21, P = 0.0313; W₅ = 21, P = 0.0313, n = 6, respectively). M₁KO, M₁ muscarinic acetylcholine receptor knockout; PV, parvalbumin; sIPSC, spontaneous inhibitory postsynaptic current; WT, wild-type.