Fig. 3.

Eptifibatide inhibits fibrin deposition and platelet accumulation. Eptifibatide (10 µg/g body weight) was infused into C57BL/6 wild type mice before injury and reinfused every 20 minutes for subsequent thrombi as described [25]. (A) Fibrin deposition; (B) platelet accumulation. In some experiments wild type ERp57 (ss-ss) was infused (200 µg/mouse) 10 minutes prior to the first dose of eptifibatide. The median integrated fluorescent intensities (FI) were obtained from a total of 30 thrombi in 3 mice per group.