FIGURE 7.

Representative photomicrographs from the primary tumor (A and B) and the vertebral metastasis (C and D) of case 10. The primary tumor demonstrated stereotypical low-grade features with ISUP nucleolar (nuclear) grade 2. In the metastasis documented 30 years later, the tumor demonstrated high-grade nuclear features but still showed negative staining for SDHB. As the patient had a contralateral renal tumor, which was unbiopsied at the time of metastatic disease, this may represent spread from a second primary tumor (hematoxylin and eosin).