Table 1.

Effects of CCK or TPA stimulation in rat pancreatic acini, with or without modulation of the activation of SFK (^a).

	Stimulation
Variable	Yes	No
I. Kinase stimulation
By 100 nM CCK (b)	Src, PYK2, p125FAK, Paxillin, PKD, MARCKS, p130CAS, Shc, p42/44, JNK, p38 and Akt (inhibited).	GSK3-β.
By 0.3 nM CCK (c)	Src, PYK2, p125FAK, Paxillin, PKD, p42/44.	p130CAS, Shc, p38, JNK, GSK3-β, MARCKS.
By 1 µM TPA (b, c)	Src, PYK2, p125FAK, paxillin, PKD, MARCKS, p130CAS, Shc, p42/44, JNK and Akt (inhibited).	p38, GSK3-β.
II. Kinase inhibition by 10 µM PP2
Of basal (b, c)	Src, PYK2, Paxillin, p130CAS, Shc, p42/44, GSK3-β, Akt.	p125FAK, PKD, MARCKS, p38, JNK.
Of 100 nM CCK kinases stimulation (b)	Src, PYK2, p125FAK, Paxillin, p130CAS, Shc.	PKD, MARCKS, p42/44, p38, JNK, GSK3-β, Akt.
Of 0.3 nM CCK stimulation (c)	Src, PYK2, Paxillin.	p125FAK, PKD, p130CAS, Shc, p42/44, p38, JNK, GSK3-β, MARCKS.
Of 1 µM TPA stimulation (b, c)	Src, PYK2, p125FAK, Paxillin, p130CAS, Shc.	PKD, p42/44, p38, JNK, GSK3-β, MARCKS, Akt.
III. DN-CSK-Advirus kinase Basal stimulation (d)	Src, PYK2, p125FAK, Paxillin, p130CAS, Shc.	PKD, p42/44, p38, JNK, GSK3-β.
IV. WT-CSK-Advirus kinase Basal stimulation (d)	Src, PYK2, p125FAK, Paxillin, p130CAS, Shc	PKD, p42/44, p38, JNK, GSK3-β.

^aResults are calculated from the data shown in Figs. 1–4, 6–8

^bResults are calculated from the data shown in Figs. 1–2

^cConcentration and incubation times are reported in Figs. 3–4

^dConcentrations and incubation time are reported in Figs. 6–8