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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: J Pathol. 2014 Sep 30;234(4):478–487. doi: 10.1002/path.4417

Figure 6.

Figure 6

A progenitor cell model for the fallopian tube in which Krt7 identifies the progenitor cell and PAX2n defines progenitor cell expansion. Expanding PAX2n cells can differentiate into basal or ciliated cells in WCNs or Type 1 SCOUTs, both of which approximate normal differentiation pathways, with loss of ALDH1 and normal or minimally increased expression of LEF1, RCN1, Stathmin and EZH2. In contrast, Type 2 SCOUTs and STINs (right) share a different expression signature characterized by multiple genes, including EZH2, LEF1, RCN1, and stathmin and others involved in a divergent pathway of progenitor cell growth.