Table 5.

PK Parameter Estimates After a Single 10 or 20 mg/kg Dose

Subject	Dose mg/kg	Rsq adjusted	# points lambda z	Lambda z lower day	Lambda z upper day	HL day	Tmax day	Cmax μg/mL	Cmax/Dose kg*μg/mL/mg	AUC day*μg/mL	AUC/dose day*kg*μg/mL/mg	V mL/kg	CL mL/day/kg
1104	10	0.9766	3	154.2	259	10.49	42.20	681.0	68.10	37,903	3,790	26.45	1.748
1301	10	0.9902	4	167.2	226	11.14	42.20	257.0	25.70	18,360	1,836	55.80	3.471
1302	10	0.9998	3	169.2	199	12.03	155.20	337.9	33.79	23,765	2,377	43.14	2.486
1901	10	0.9989	3	161	226	15.10	42.20	495.81	49.58	32,920	3,292	36.41	1.672
Mean						12.19		442.9	44.29	28,237	2,824	40.45	2.34
STD						2.04		187.1	18.71	8,811	881	12.32	0.84
CV%						16.74		42.3	42.3	31.2	31.2	30.5	35.7
1105	20	0.8425	3	56.2	114	18.80	14.00	720.569	36.03	23,887	1,194	54.49	2.009
1107	20	0.9618	3	162.2	220	10.76	27.20	652.373	32.62	45,822	2,291	38.75	2.495
1902	20	0.9065	4	154.2	203	13.30	154.20	1,100.950	55.05	63,145	3,157	24.44	1.274
Mean						14.29		824.6	41.23	44,285	2,214	39.23	1.93
STD						4.11		241.7	12.09	19,674	984	15.03	0.62
CV%						28.75		29.3	29.3	44.4	44.4	38.3	31.9

Abbreviations: STD, Standard deviation; CV%, Coefficient of variation; RSQ adjusted, Goodness of fit statistic for the terminal elimination phase adjusted for the number of points used in the estimation of λ_z; # points lambda z=number of points in the terminal elimination phase used to calculate λ_z; HL, apparent terminal elimination half life; T_max, Time to reach C_max; C_max, Maximum observed concentration, occurring at T_max; C_max/Dose, Maximum observed concentration normalized by dose; V, volume of distribution based on the terminal phase; CL, systemic clearance; AUC, area under the concentration-time curve