Initial and final infarct and hypoperfused volumes for patients presenting with M1 and M2 occlusions. Compared with patients who presented with M1 occlusions, patients with M2 occlusions presented with (A) smaller infarcts (15 vs 11 mL, p<0.05) and (B) smaller hypoperfused volumes (84 vs 46 mL, p<0.001). Compared with patients who presented with M1 occlusions, patients with M2 occlusions had (C) smaller final infarcts volumes (52 vs 22 mL, p<0.001). For the subsets of patients who achieved (D) Thrombolysis in Cerebral Infarction (TICI) 0–2a or (E) TICI 2b/3 reperfusion, final infarct volumes were also smaller in M2 than M1 occlusions (74 vs 51 mL, p<0.05 and 42 vs 8 mL, p<0.01). Each point represents an individual patient, with the median and IQR shown in red. Colored horizontal lines indicate final infarct volumes of 90 mL (blue) and 50 mL (brown). *Indicates p<0.05. DWI, diffusion-weighted imaging; PWI, perfusion-weighted imaging.