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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Ann Rheum Dis. 2014 Feb 23;74(6):1284–1292. doi: 10.1136/annrheumdis-2013-204782

Figure 4. IL-17A exacerbates synovial inflammation and bone loss in inflammatory arthritis.

Figure 4

a) Disease severity score of C57BL/6 mice post-gene transfer of IL-17A or GFP, immunized and challenged with bovine collagen type II. Data pooled from 2 experiments and a total of 20 mice analyzed. b) Representative photographic images of inflamed mouse paws post-GFP (left) and post-IL-17A (right) gene transfer at day 37 post collagen-induced arthritis initiation showing severe inflammation in the IL-17A gene transfer. c) H&E staining of tissue sections of paws showing infiltration of mononuclear cells, synovial lining cell hyperplasia, destruction of joint cartilage layers, and fibrous ankylosis post IL-17A gene transfer. d) Micro-CT of mouse paws showing severe bone erosion present in IL-17A MC (right) compared to GFP controls (left). e) Relative gene expression of RANKL, TRAP5b and MMP9 from mouse paws at 37 days post collagen-induced arthritis initiation (Data pooled from 4 mice).