Table 3.
Genetic Moderation of Depressive Reactivity to Victimization: BDNF Val66Met
| VictimizationOnly | Additive Model | Interaction Model | ||||
|---|---|---|---|---|---|---|
| B (SE) | p-value | B (SE) | p-value | B (SE) | p-value | |
| Fixed Effects | ||||||
| Intercept | .01 (.05) | .91 | .02 (.05) | .74 | .02 (.05) | .66 |
| Grade | .01 (.02) | .67 | .01 (.02) | .70 | .01 (.02) | .74 |
| White | .13 (.05) | .01 | .17 (.05) | <.01 | .17 (.05) | <.01 |
| Male | −.18 (.05) | <.001 | −.19 (.05) | <.001 | −.19 (.05) | <.001 |
| Victimization | .29 (.08) | <.001 | .27 (.08) | <.01 | .14 (.10) | .14 |
| BNDF Val66Met | −.13 (.11) | .25 | −.17 (.11) | .13 | ||
| Victimization* BNDF Val66Met | .75 (.31) | .02 | ||||
| Random Effects | ||||||
| Intercept Variance | .65 (.07) | <.001 | .65 (.07) | <.002 | .66 (.07) | <.001 |
| Grade Variance | .03 (.01) | .02 | .03 (.01) | .03 | .03 (.01) | .03 |
| Victimization Variance | .47 (.13) | <.01 | .39 (.13) | <.01 | .36 (.13) | <.01 |
| Residual Variance | .35 (.13) | <.01 | .46 (.02) | <.001 | .46 (.01) | <.001 |
| Model Fit | ||||||
| AIC | 8228.8 | 7926.6 | 7935.2 | |||
| BIC | 8264.2 | 7991.9 | 7970.3 | |||
Note. BDNF is scored additively with each Met allele = .5 and each Val allele = 0 (for a total score between 0–1). Grade is centered at 8th grade, depressive symptoms are standardized, andvictimization is scored as present or absent. AIC = Akaike Information Criterion (lower is better). BIC = Bayesian Information Criterion (lower is better). Substantively interesting parameter estimates are bolded.